Last steps in escort aptamer preparing cover man-made improvement of the truncated aptamer
Last steps in escort aptamer preparing cover man-made improvement of the truncated aptamer Further nuclease stabilization is achieved by substitution of 2?-OCH3 for 2?-OH at purine positions. As the 2?-OCH3 moiety is not compatible with current SELEX process enzymes, this alteration must occur during chemical synthesis following evolution of a specific aptamer sequence. Generally, most …