Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) Oplev mere her format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Biological targets and you can pharmacology of curcumin
Publication ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin ‘s the biggest element of the latest reddish dye away from turmeric, a keen Indian spice that is taken from this new rhizome of one’s warm bush Curcuma longa, hence is one of the Zingiberaceae family unit members. Contained in this part, we talk about the pharmacological products from curcumin and you may discuss the brand new molecular bases for those things. We after that remark the latest proven and you will possible health-related spends off curcumin. Curcumin is famous usually given that a healing representative, but the apparatus of action was outlined. The fresh new pharmacological ramifications of curcumin seem to be the result of a synergism out-of networks regarding weak biochemical affairs which have several physical needs when you look at the interconnected signaling routes. These objectives is nutrients for example cyclooxygenase, lipoxygenase and you can healthy protein kinases, and transcription facts such as NF-?B, STAT and Nrf2. Modulation of them molecules influences downstream affectors that make the brand new antiinflammatory, antioxidant, chemopreventive, anticancer, and you will antimicrobial products away from curcumin. This type of outcomes was checked-out in clinical products of curcumin for discomfort and inflammatory ailment, disease, Alzheimer condition, cardiovascular sickness, and you can all forms of diabetes. The newest products purchased varying amounts out-of curcuminwith additional wavelengths and period, to your general completion you to definitely higher amounts out-of curcumin during the quantity of grams must obtain therapeutic effects. Find out more
Curcumin: Synthesis, Emerging Role within the Problems Administration and you may Fitness Effects
Publication Chapter Examples of plant-derived pharmaceuticals which have become the focus off continued and you will rapid search and you may invention appeal provides, at this point, been somewhat scarce. Once many years, the last twenty years was in fact described as a beneficial 100-flex escalation in how many scientific blogs composed per year one are out of significance towards the entry to curcumin during the biomedicine. Read more
Structure, synthesis and physical factors from curcumin prodrugs
Guide ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin has many prospective pharmacological consequences and may also provides healing applications a number of condition says, since the chatted about in detail in the earlier chapter. However, the possibility systematic efficacy off curcumin is restricted by the physicochemical characteristics out of poor drinking water solubility and you will instability, and this bring about low bioavailability. Prodrugs out-of curcumin render a way to upgrade of the biopharmaceutical and you can pharmacokinetic characteristics, that will enable it to be exploitation of your pharmacological results of curcumin. Contained in this chapter, i earliest opinion this new physicochemical and you may pharmacokinetics of curcumin. We upcoming define the appearance of curcumin prodrugs that have enhanced liquid solubility and you can enhanced chemical balances which are often converted to free curcumin abreast of bioactivation during the vivo. I high light previous triumph in this area, having a focus on the framework, synthesis and you may comparison from prodrugs predicated on promoieties and additionally proteins, efas, nucleic acids, dicarboxylic acids, and you can polymeric content such as for example hyaluronic acidic and you may polyethylene glycol. So it part has got the basis for optimisation of your own physicochemical and you will biopharmaceutical services and also the physical factors out of curcumin prodrugs, on mission playing with of those curcumin derivatives into the logical software. Find out more